Reports of Biochemistry and Molecular Biology

en Usefulness of A Random Spot Urine Proteins-to-Creatinine Ratio to Screen for Increased Albuminuria in Patients with Type 1 Diabetes بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: Moderately increased albuminuria is a biomarker for early onset diabetic nephropathy. The aim of this study was to evaluate the performance of use proteinuria-to-creatininuria ratio (UPCR) at different cut-off to screen for increased albuminuria using albuminuria-to-creatininuria ratio (UACR) as a gold standard.  Methods: This was a cross-sectional study. A random spot urine sample was collected from patients with type 1 diabetes to measure albuminuria and total proteinuria using respectively an immunoturbidimetric and a colorimetric assay. Albuminuria was expressed as UACR and proteinuria as UPCR. The area under the curve (AUC) method and the kappa coefficient were used to compare UPCR and UACR. Results: In 150 diabetic patients, moderately increased albuminuria was detected in 33.3% using UACR and 35.3% using UPCR at 272 mg/g. UPCR thresholds of 130, 150, 180 and 200 mg/g yielded higher detection rates than UACR. However, all UPCR cut-offs showed low diagnostic accuracy (AUC < 70%), and agreement with UACR was mild (kappa < 0.40). Conclusion: The level of agreement between UPCR and UACR was moderate. It is not sufficient for UPCR to replace UACR to screen for increased albuminuria in patient with type 1 diabetes.</div> Albuminuria, Diabetes, Diabetic Nephropathyn, Kidney Diseases, Proteinuria. 561 569 http://rbmb.net/browse.php?a_code=A-10-1614-1&slc_lang=en&sid=1 El Hadji Malick Ndour elhadjimalick1.ndour@ucad.edu.sn. 100319475328460021585 100319475328460021585 Yes Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. Rokhaya Dione 100319475328460021586 100319475328460021586 No Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. Fatou Gueye-Tall 100319475328460021587 100319475328460021587 No Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. Sokhna Mara 100319475328460021588 100319475328460021588 No Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. Gora Fall 100319475328460021589 100319475328460021589 No Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. Coumba Kamby 100319475328460021590 100319475328460021590 No Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. El Hadji Ousmane Sene 100319475328460021591 100319475328460021591 No Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. Moustapha Djite 100319475328460021592 100319475328460021592 No Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. Nene Oumou Kesso Barry 100319475328460021593 100319475328460021593 No Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. Pape Matar Kandji 100319475328460021594 100319475328460021594 No Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. Papa Madieye Gueye 100319475328460021595 100319475328460021595 No Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. Philomene Lopez-Sall 100319475328460021596 100319475328460021596 No Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal. Aynina Cisse 100319475328460021597 100319475328460021597 No Senegalese National Academy of Science and Technology, Dakar Senegal.