en ایمنی شناسی Immunology مقالات مروری Review <p style="text-align: justify;">Asthma and allergic diseases cases have risen in recent decades. Plant pollen is considered as the main aeroallergen causing allergic reactions. According to available data, urban residents experience more respiratory allergies than rural residents mainly due to the interaction between chemical air pollutants and pollen grains. This interaction can occur through several mechanisms; chemical pollutants might facilitate pollen allergen release, act as adjuvants to stimulate IgE-mediated responses, modify allergenic potential, and enhance the expression of some allergens in pollen grains. This review focuses on the most recent theories explaining how air pollutants can interact with pollen grains and allergens.<br> &nbsp;</p> Allergens, Chemical air pollutants, pollen, respiratory allergy, Urban air pollution. 219 224 http://rbmb.net/browse.php?a_code=A-10-92-1&slc_lang=en&sid=1 Farnaz Sedghy fsedghy@gmail.com 10031947532846006322 10031947532846006322 No Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman. Abdol-Reza Varasteh varasteha@mums.ac.ir 10031947532846006323 10031947532846006323 Yes Immuno-Biochemistry lab, Immunology Research Center, Mashhad University of medical Sciences, Mashhad, Iran. Mojtaba Sankian Sankianm@mums.ac.ir 10031947532846006324 10031947532846006324 No Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Malihe Moghadam moghadamM1@mums.ac.ir 10031947532846006325 10031947532846006325 No Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.