en زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> Intrauterine growth restriction (IUGR), a pathologic diminution of the rate of fetal growth, has been associated with alterations in expression of several genes. However, the role of long non-coding RNAs (lncRNAs) in its pathogenesis has not been studied.<br> <br> <strong><em>Methods:</em></strong> In this study we evaluated the expression of four lncRNAs namely, nuclear paraspeckle assembly transcript (<em>NEAT1</em>), taurine up-regulated 1 (<em>TUG1</em>), p21-associated ncRNA DNA damage-activated (<em>PANDA</em>), and metastasis-associated lung adenocarcinoma transcript-1 (<em>MALAT1</em>) in placenta samples obtained from IUGR and normal pregnancies to determine their possible contributions in the pathogenesis of IUGR.<br> <br> <strong><em>Results:</em></strong> We found no significant differences in expression levels between cases and controls. We also found no correlation between expression and clinical data of study participants; however, we found significant correlations between expression levels of all the assessed lncRNAs in both cases and controls.<br> <br> <strong><em>Conclusions:</em></strong> These results imply the existence of a possible shared regulatory mechanism for the expression of these transcripts in placenta. Future studies are needed to perform such evaluations in larger sample sizes or in animal models in earlier stages of pregnancy.<br> &nbsp;</div> IUGR, NEAT1, MALAT1, PANDA, Placenta, TUG1. 25 31 http://rbmb.net/browse.php?a_code=A-10-187-1&slc_lang=en&sid=1 Iman Azari ea1369_2010@yahoo.com 100319475328460017132 100319475328460017132 No Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Soudeh Ghafouri-Fard s.ghafourifard@sbmu.ac.ir 100319475328460017133 100319475328460017133 No Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mir Davood Omrani davood_omrani@yahoo.co.uk 100319475328460017134 100319475328460017134 No Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Shahram Arsang-Jang shahramarsang@gmail.com 100319475328460017135 100319475328460017135 No Clinical Research Development Center (CRDU), Qom University of Medical Sciences, Qom, Iran. Dor Mohammad Kordi Tamandani kord_dor@yahoo.com 100319475328460017136 100319475328460017136 No Department of Biology, University of Sistan and Baluchistan, Zahedan- Iran. Mehrnaz Saroone Rigi M_rigi@yahoo.com 100319475328460017137 100319475328460017137 No Shafa Surgery Center, Zahedan, Sistan and Baluchistan, Iran. Sara Rafiee s_rafiee@yahoo.com 100319475328460017138 100319475328460017138 No Department of Biology, University of Sistan and Baluchistan, Zahedan- Iran. Farkhondeh Pouresmaeili pouresfar@gmail.com 100319475328460017139 100319475328460017139 No Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. & Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Taheri mohammad_823@yahoo.com 100319475328460017140 100319475328460017140 Yes Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.