en زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> Long non-coding RNAs (lncRNAs) have been considered to be prospective biomarkers for diagnosing lung cancer due to the fundamental roles they hold in the regulating several cancer-related pathways. &nbsp;<br> <br> <strong><em>Methods:</em></strong> Using the quantitative real-time polymerase chain reaction method, we evaluated the expression of <em>CCAT2</em>, <em>UCA1</em>, <em>PANDA</em> and <em>GHET1</em> lncRNAs in 32 lung cancer tissue samples and their corresponding adjacent non-cancerous tissues (ANCTs) from lung cancer patients admitted to the Labbafi-Nejad Hospital from 2015 to 2016.<br> <br> <strong><em>Results:</em></strong> No significant differences were found in the expression of lncRNAs within the tumoral and non-tumoral tissue samples. Bayesian Multilevel analysis showed no association between the expression of lncRNAs and the patient&rsquo;s tumor node metastasis (TNM) stage following adjustments for age. Spearman correlation analysis revealed an inverse correlation between the expression of <em>PANDA</em> in tumoral tissues and age. Additionally, the difference in <em>CCAT2</em> expression among the tumoral and non-tumoral tissues was inversely correlated with patients&#39; age. Significant pairwise correlations were found between the expression of lncRNAs in both the tumoral and non-tumoral tissues.<br> <br> <strong><em>Conclusions:</em></strong> Despite the findings supporting a role for the lncRNAs, <em>CCAT2</em>, <em>UCA1</em>, <em>PANDA</em> and <em>GHET1</em> in the pathogenesis of lung cancer, our data suggests no relationship for expression of these lncRNAs in lung cancer, questioning their potential as lung cancer biomarkers.<br> &nbsp;</div> CCAT2, GHET1, lncRNAs, Lung cancer, PANDA, UCA1 36 41 http://rbmb.net/browse.php?a_code=A-10-187-3&slc_lang=en&sid=1 Farbod Esfandi fabod64@hotmail.com 100319475328460017146 100319475328460017146 No Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran & GenIran Lab, Tashkhis Gene Pajohesh, Tehran, Iran. Hamid Fallah hfallah1018@yahoo.com 100319475328460017147 100319475328460017147 No Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Shahram Arsang-Jang shahramarsang@gmail.com 100319475328460017148 100319475328460017148 No Clinical Research Development Center (CRDU), Qom University of Medical Sciences, Qom, Iran. Mohammad Taheri mohammad_823@yahoo.com 100319475328460017149 100319475328460017149 Yes Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Soudeh Ghafouri-Fard s.ghafourifard@sbmu.ac.ir 100319475328460017150 100319475328460017150 No Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.