en زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> Abnormal expression of <em>ABCC</em> transporter genes has been associated with treatment failure in pediatric patients with acute lymphoblastic leukemia (ALL). The aim of this study was to evaluate the expression pattern of <em>ABCC1-6</em> and <em>ABCC10</em> genes in Iranian pediatric patients with ALL relapse and determine the potential predictive value of determining ALL relapse from <em>ABCC </em>expression.<br> <br> <strong><em>Methods:</em></strong> Patients with ALL were divided into two separate groups, either the case group with relapsed ALL or the control group in which ALL patients have been in progression-free survival for at least 3 years A total of thirty-nine participants (23 with relapsed ALL; 16 controls) were enrolled over 26 months. To determine the levels of <em>ABCC1-6 </em>and <em>ABCC10 </em>transporter gene expression RT-PCR was used. Cumulative doses of the chemotherapy drugs, VCR, DNR and L-ASP, were calculated for each patient.<br> <br> <strong><em>Results:</em></strong> Our findings showed elevated expression of <em>ABCC2-6 </em>and decreased expression of <em>ABCC1</em> and <em>ABCC10</em> to be associated with an increased risk of ALL relapse. The mean-fold expression of <em>ABCC2 </em>was significantly increased in the ALL relapse group. Additionally, the expression pattern of the <em>ABCC </em>transporter genes was associated with high doses of three chemotherapy drugs, VCR, DNR and L-ASP.<br> <br> <strong><em>Conclusions:</em></strong> Evaluating the expression pattern of <em>ABCC </em>transporter genes may be a potential biomarker for predicting the occurrence of ALL relapse in Iranian pediatric patients and improve cancer prognosis.<br> &nbsp;</div> ABC transporters, ‍Childhood, Gene expression, Pattern, Recurrence. 184 193 http://rbmb.net/browse.php?a_code=A-10-315-1&slc_lang=en&sid=1 Narjes Mehrvar narjes.mehrvar@gmail.com 100319475328460017284 100319475328460017284 No Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hassan Abolghasemi pchd1391@gmail.com 100319475328460017285 100319475328460017285 No Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Reza Rezvany mohrezrez@yahoo.com 100319475328460017286 100319475328460017286 No Hematology department, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran. & Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden. Mohammad Esmaeil Akbari crccbils@gmail.com 100319475328460017287 100319475328460017287 No Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Javad Saberynejad javad.saberynejad@gmail.com 100319475328460017288 100319475328460017288 No AJA University of Medical Sciences, Tehran, Iran. Azim Mehrvar drazimmehrvar@yahoo.com 100319475328460017289 100319475328460017289 No AJA University of Medical Sciences, Tehran, Iran. & Mahak Hematology Oncology Research Center (Mahak-HORC), Mahak Hospital, Tehran, Iran. Mohammad Ali Ehsani maehsani@gmail.com 100319475328460017290 100319475328460017290 No Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mahyar Nourian mahyarnourian1369@gmail.com 100319475328460017291 100319475328460017291 No Mahak Hematology Oncology Research Center (Mahak-HORC), Mahak Hospital, Tehran, Iran. Ibrahim Qaddoumi ibrahim.qaddoumi@stjude.org 100319475328460017292 100319475328460017292 No Department of Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, TN USA. Abolfazl Movafagh movafagh_a@yahoo.com 100319475328460017293 100319475328460017293 Yes Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. & Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran