en زیست شناسی ملکولی Molecular Biology گزارش مورد Case Report <div style="text-align: justify;"><strong><em>Background:</em></strong> Coronary arteries disease (CAD) has been recognized as one of the most common causes of death worldwide, with an estimated seven million deaths annually.<br> <br> <strong><em>Methods:</em></strong> Two hundred blood samples from Iranian CAD patients and normal healthy controls were collected. CAD and the 9p21 locus variants <em>rs1333049</em> and <em>rs10757278</em> were analyzed for potential associations.<br> <br> <strong><em>Results</em></strong><strong><em>:</em></strong> No significant differences in <em>rs10757278</em> and <em>rs1333049</em> polymorphisms were found between patients and controls, but a significant relationship was found between <em>rs10757278</em> and <em>rs1333049</em> in CAD patients at the genotype level (p= 0.0323). At the haplotype level and on the basis of diplotype analysis, a significant relationship was found between patients and controls (OR= 5.16, p= 0.047, 95% CI: 1.02-26.0). In CAD patients, <em>rs10757278</em> and <em>rs1333049</em> were associated at locus 9p21.<br> <br> <strong><em>Conclusions:</em></strong> The inconsistency between the results of this and other studies on different CAD populations may be due to high population, different ethnicities, low prevalence of some alleles in populations, and interactions of different genes.</div> rs1333049, rs10757278,9p21, Coronary artery disease (CAD), Tetra ARMS 58 63 http://rbmb.net/browse.php?a_code=A-10-482-1&slc_lang=en&sid=1 Farbod Yaghoubi Hariri farbodya@yahoo.com 100319475328460017509 100319475328460017509 No Department of biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Iman Salahshourifar isalahshouri@gmail.com 100319475328460017510 100319475328460017510 Yes Department of biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Shohreh Zare Karizi shohrehzare@yahoo.com 100319475328460017511 100319475328460017511 No Department of Genetics and Biotechnology, School of Biological Science, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran.