en بیوشیمی Biochemistry <p style="text-align: justify;">Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. It has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. Thrombophilia is an important predisposition to blood clot formation and is considered as a significant risk factor for recurrent pregnancy loss. The inherited predisposition to thrombophilia is most often associated with factor V Leiden mutation, prothrombin G20210A mutation, and methylenetetrahydrofolate reductase C677T and A1298C gene variants. The net effect is an increased cleavage of prothrombin to thrombin and excessive blood coagulation.</p> Hereditary thrombophilia, Factor V Leiden mutation, Recurrent pregnancy loss 98 102 http://rbmb.net/browse.php?a_code=A-10-1-29&slc_lang=en&sid=1 Reza Ebrahimzadeh-Vesal rz_ebrahimzadeh@yahoo.com 10031947532846006004 10031947532846006004 Yes Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Roza Azam 10031947532846006005 10031947532846006005 No Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Arvin Ghazarian 10031947532846006006 10031947532846006006 No Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Mogge Hajesmaeili 10031947532846006007 10031947532846006007 No Department of Biology, Islamic Azad University of Parand, Tehran, Iran. Najmeh Ranji 10031947532846006008 10031947532846006008 No Department of Genetics, Faculty of Sciences, Islamic Azad University, Rasht Branch, Rasht, Iran. Mohammad Reza Ezzati 10031947532846006009 10031947532846006009 No Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Mehrdad Sadri 10031947532846006010 10031947532846006010 No Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Ali Mohammadi 10031947532846006011 10031947532846006011 No Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Siamak Khavandi 10031947532846006012 10031947532846006012 No Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.