Reports of Biochemistry and Molecular Biology
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Basic Sciences
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2322-3480
2322-3480
10.61882/rbmb
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gregorian
2021
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Analysis of Micro-RNA-144 Expression Profile in Patients with Multiple Sclerosis in Comparison with Healthy Individuals
زیست شناسی ملکولی
Molecular Biology
مقالات اصلی
Original Article
<div style="text-align: justify;"><strong><em>Background:</em></strong> Etiology of multiple sclerosis is non-clarified. It seems that environmental factors impact epigenetic in this disease. Micro-RNAs (MIR) as epigenetic factors are one of the most important factors in non-genetically neurodegenerative diseases. It has been found MIR-144 plays a main role in the regulation of many processes in the central nervous system. Here, we aimed to investigation of MIR-144 expression alteration in Multiple sclerosis (MS) patients. <br>
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<em><strong>Methods: </strong></em>In this study 32 healthy and 32 MS patient's blood sample were analyzed by quantitative Real-Time PCR method and obtained data analyzed by REST 2009 software. <br>
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<strong><em>Results:</em></strong> Analysis of Real-Time PCR data revealed that miR-144 Increase significantly in MS patients compared to healthy controls. Conclusions: The increase of MIR-144 expression in MS patients is obvious. MIR-144 can be used as a biomarker of MS and help to early diagnosis and treatment of this disease.<span dir="RTL"></span></div>
MicroRNA (miRNA), MiRNA-144, Multiple Sclerosis (MS).
396
401
http://rbmb.net/browse.php?a_code=A-10-520-1&slc_lang=en&sid=1
Fatemeh
Roshani
100319475328460012533
100319475328460012533
No
Department of Genetics, Nourdanesh Institute of higher Education, Myme, Esfahan, Iran.
Hossien
Delavar Kasmaee
100319475328460012534
100319475328460012534
No
medical university of Shahid Beheshti, Tehran, Iran.
Kowsar
Falahati
100319475328460012535
100319475328460012535
No
Medical Genetic Department, National Institute of Genetics Engineering and Biothechnology, Tehran, Iran.
Ghazaleh
Arabzadeh
100319475328460012536
100319475328460012536
No
Department of Genetics, Nourdanesh Institute of higher Education, Myme, Esfahan, Iran.
Atefeh
Aohan Forooshan Moghadam
100319475328460012537
100319475328460012537
No
Department of Genetics, Nourdanesh Institute of higher Education, Myme, Esfahan,Iran.
Mohammd Hossein
Sanati
m-sanati@nigeb.ac.ir.
100319475328460012538
100319475328460012538
Yes
Medical Genetic Department, National Institute of Genetics Engineering and Biothechnology, Tehran, Iran.