en زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> Noise-induced hearing loss (NIHL) can cause damage to the cochlea. Curcumin and nuclear&nbsp;factor erythroid 2-related factor 2 (NRF2) are transcription activators that play a crucial role in defence&nbsp;mechanisms against oxidative stress. The aim of this study was to determine the effect of curcuminoid&nbsp;administration on NRF2 expression, in the organ of Corti of cochlea of Rattus norvegicus that were exposed&nbsp;to noise, from the results of the distortion product otoacoustic emission (DPOAE) examination.<br> <br> <strong><em>Methods:</em></strong> We divided 36 rats into six groups including Group 1 (control); Group 2 (noise exposure without&nbsp;curcuminoid administration); Group 3 (noise exposure+curcuminoid dose 100 mg/day for four days); Group&nbsp;4 (noise exposure+curcuminoid dose 200 mg/day for four days); Group 5 (curcuminoid dose of 100 mg/day&nbsp;for 14 days followed by two days of noise exposure); Group 6 (curcuminoid dose 200 mg/day for 14 days&nbsp;followed by two days of noise exposure).&nbsp;<br> <br> <strong><em>Results:</em></strong> Following noise exposure in rats, there was an effect/correlation between NRF2 expression, the SNR&nbsp;values obtained from DPOAE and curcuminoid administration.&nbsp;Conclusions: There was a correlation between curcuminoid administration, NRF2 expression and DPOAE&nbsp;treatment. Following noise exposure in rats (Rattus norvegicus), SNR values obtained from DPOAE showed&nbsp;improved cochlear function.</div> Curcuminoid, Distortion Product Otoacoustic Emission, Noise Induced Hearing Loss, Oxidative Stress, Nuclear factor erythroid 2-related factor 2. 373 379 http://rbmb.net/browse.php?a_code=A-10-668-1&slc_lang=en&sid=1 Tengku siti Hajar Haryuna tengkusitihajarharyuna@usu.ac.id. 100319475328460012521 100319475328460012521 Yes Department of Otorhinolaryngology, Faculty of medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, Indonesia. Diana Amellya 100319475328460012522 100319475328460012522 No Department of Otorhinolaryngology, Faculty of medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, Indonesia. Delfitri Munir 100319475328460012523 100319475328460012523 No Department of Otorhinolaryngology, Faculty of medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, Indonesia. Tengku Siti Harilza Zubaidah 100319475328460012524 100319475328460012524 No Department of Ophtalmology, Faculty of medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, Indonesia.