en بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;"><em><strong>Background:</strong></em> Epilepsy is one of the most widespread neurological disease worldwide. Status epilepticus&nbsp;(SE) is a life-threatening neurologic disorder. Neuroprotective approaches are increasingly to discover a&nbsp;promising therapy to manage epileptic disorders. This study aimed to assess the impact of berberine on&nbsp;some epigenetic, transcription regulation & inflammatory biomarkers in a mice model of epilepsy.<br> <br> <strong><em>Methods:</em></strong> This work was performed on; Group I: (control), Group II: berberine‐treated control,&nbsp;Group III: epilepsy group, Group IV: berberine‐treated epilepsy. Groups were subjected to&nbsp;assessment of Tumor growth factor-1ꞵ (TGF-1ꞵ), hypoxia inducible factor-1&alpha; (HIF-1&alpha;), brain derived&nbsp;neurotrophic factor (BDNF) levels, histone deacetylase (HDAC) activity & neuronal restrictive silencing&nbsp;factor (NRSF) gene expression.<br> <br> <strong><em>Results:</em></strong> Study showed significant increase in levels of HIF-1&alpha;, TGF-1&beta;, HDAC activity & NRSF gene&nbsp;expression in epilepsy group & decrease in these levels in berberine treated epilepsy group. Significant&nbsp;decrease in BDNF levels in epilepsy & elevation in them in berberine treated epilepsy group.<br> Conclusions: Our study showed the anti-epileptic impact of berberine via its regulatory effect on some epigenetic,&nbsp;transcription factors & inflammatory biomarkers in a mice model of epilepsy.&nbsp;</div> Berberine, Epigenetics, Epilepsy, Transcription regulation & inflammatory biomarkers. 362 372 http://rbmb.net/browse.php?a_code=A-10-703-1&slc_lang=en&sid=1 Heba Bassiony Ghanem ghanemhb@yahoo.com. 100319475328460012517 100319475328460012517 Yes Clinical laboratory sciences Department, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia & Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt. Marwa Nagy Emam 100319475328460012518 100319475328460012518 No Physiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. Dareen Abdelaziz Mohammed Ali 100319475328460012519 100319475328460012519 No Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. Rania Nagi Abd-Ellatif 100319475328460012520 100319475328460012520 No Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.