en زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><em><strong>Background</strong></em>: Cervical cancer is the fourth most deadly cancer in the world, and it is caused by infection of&nbsp;high-risk subtypes of Human PapillomaVirus (HPV) in most cases. The aims of this study were to determine&nbsp;the prevalence oncogenic HPV in cervical cancer patients in Riau Province Indonesia and to determine the&nbsp;clinical manifestation of HPV in cervical cancer patients in Riau Province Indonesia.<br> <br> <em><strong>Methods</strong></em>: This research was a descriptive study conducted at Arifin Achmad General Hospital Riau&nbsp;from February to August 2018 which aimed to analyze HPV genotype prevalence oncogenic of&nbsp;cervical cancer patients.<br> <br> <em><strong>Results:</strong></em> This study showed out 86 of 110 women (78.1%) were found HPV positive, and the most&nbsp;common genotype of HPV was HPV 16 (38.2%). The average age of cervical cancer patient was 50 years&nbsp;old, and the average number of parities was 4 times. The majority of participants were married at the age&nbsp;before 20 years (77.3%) and had low educational background (64.5%). Vaginal bleeding happened in&nbsp;more than half of the participant as major clinical manifestation (72.7%), followed by fluor albus (72.7%),&nbsp;pelvic pain (60.2%) and fatigue (65.9%).<br> <br> <strong><em>Conclusions:</em></strong> The most common HPV genotype in Riau Province was HPV type 16 and the most&nbsp;common clinical symptoms of cervical cancer patient were vaginal bleeding, fluor albus, pelvic pain&nbsp;and fatigue.</div> Cervical cancer, Clinical manifestations Human Papilomavirus, Human Papilomavirus genotype prevalence. 573 579 http://rbmb.net/browse.php?a_code=A-10-660-2&slc_lang=en&sid=1 Maya Savira mayadonel@yahoo.co.id. 100319475328460012419 100319475328460012419 Yes Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia & Microbiology Department, Faculty of Medicine, Universitas Riau, Pekanbaru, Riau, Indonesia. Donel Suhaimi 100319475328460012420 100319475328460012420 No Obstetry & Gynecology Department, Faculty of Medicine, Universitas Riau, Arifin Achmad General Hospital, Pekanbaru, Riau, Indonesia. Andani Eka Putra 100319475328460012421 100319475328460012421 No Microbiology Department, Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia. Yusrawati Yusrawati 100319475328460012422 100319475328460012422 No Obstetry & Gynecology Department, Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia. Nur Indrawati Lipoeto 100319475328460012423 100319475328460012423 No Clinical Nutrition Department, Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia.