en زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> Hyperglycemia and accumulation of advanced glycation end products (AGEs) play a&nbsp;significant role in the development of diabetic nephropathy. Andrographis paniculata (AP) is a plant with&nbsp;high flavonoid content with the potential to suppress oxidative stress activity in cells and tissue. This study&nbsp;was aimed to investigate the role of Andrographis paniculata extract (APE) in protecting kidney damage&nbsp;due to the formation of AGEs in the renal glomerulus in diabetic rats.<br> <br> <em><strong>Methods:</strong></em> A total of 30 male Sprague Dawley rats were randomly divided into five groups as follows:&nbsp;normal control group, streptozocin (STZ) induced diabetic group, STZ-induced diabetic group with&nbsp;AP extract (100 mg/kg BW), STZ-induced diabetic rats with AP extract (200 mg/kg BW), and STZinduced<br> diabetic rats with APE (400 mg/ kg BW). Blood glucose levels were measured before&nbsp;treatment and after treatment. Serum and urine parameters were determined. Antioxidant enzymes&nbsp;and lipid peroxide levels were determined in the kidney along with histopathological examination.<br> <br> <strong><em>Results:</em></strong> The finding of this study showed that treatment APE at the dose of 200 mg/kg and 400 mg/kg&nbsp;ameliorated kidney hypertrophy index. SOD, catalase, and GSH activities significantly decreased in&nbsp;the kidney of STZ-diabetic rats compared to the normal control rats. Treatment with APE<br> significantly decreased malondialdehyde level at the dose of 200 and 400 mg/kg BW.<br> <br> <em><strong>Conclusions:</strong></em> This study revealed evidence for improving diabetic retinopathy in male rats treated&nbsp;with Andrographis paniculata extract. APE significantly decreased oxidative stress activities in&nbsp;kidney of diabetic rats.</div> Andrographis, Diabetic Nephropathies, Streptozocin, Rats, Oxidative Stress. 445 454 http://rbmb.net/browse.php?a_code=A-10-747-1&slc_lang=en&sid=1 Rachmat Hidayat dr.rachmat.hidayat@gmail.com. 100319475328460012554 100319475328460012554 Yes Department of Biology, Faculty of Medicine, Universitas Sriwijaya. Patricia Wulandari 100319475328460012555 100319475328460012555 No Department of Biological Psychiatry, Cattleya Mental Health Center, Jl Sirnaraga No 99 Kel 8 Ilir, Palembang, 30662, Indonesia.