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The Cytokines Responses against Parvovirus B19 in Miscarriage Women and the Susceptibility of their RhD Blood Type to
Contract Parvovirus B19 in South of Iraq
زیست شناسی سلولی
Cell Biology
مقالات اصلی
Original Article
<strong><em>Background: </em></strong>Parvovirus B19 (B19) infection is linked with various diseases. Cytokines play critical roles in cellular response to viral infection. It has also been reported that’s susceptibility of the ABO blood type people to several viral infection. In this study, we evaluated interleukin 6 (IL-6), interleukin 8(IL-8), and interferon gamma (IFN-γ) levels in aborted women infected with parvovirus B19 (B19+/Abr+) and uninfected with B19(B19-/Abr+) in comparison with healthy women (B12-/Abr-) and susceptibility of their RhD blood type to contract B19.<br>
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<strong><em>Methods:</em></strong> B19+/Abr+ were diagnosed using IgM and IgG antibodies against B19, and the concentrations of IL-6, IL-8, and IFN-γ were determined using enzyme-linked immunosorbent assay (ELISA) test in both B19+/Abr+, B19-/Abr+, and B19-/Abr-. Here, we also collected blood groups, number of abortion, and gestational ages from 200 B19+/Abr+ along with the same number ofB19-/Abr+ and B19-/Abr-.<br>
<br>
<strong><em>Results:</em></strong> The levels of IFN-γ were higher in serum of B19-/Abr+andB19+/Abr+ group in comparison to B19-/Abr-, while the serum levels of IL-6, IL-8were increased in B19+/Abr+ group in comparisontoB19-/Abr+ and B19-/Abr-. Our analyzed data also showed that aborted women with RhD+ are more susceptible to contract s B19 than people with RhD- blood type.<br>
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<strong><em>Conclusions:</em></strong> B19 infection may differently modulate the amount of cytokines in the plasma of aborted women. So, it can be suggested that IL-6, IL-8, and IFN-γ potentially useful as markers for inflammation intrauterine. The susceptibility/protection of aborted women against B19 might be determined based on RhD blood type.
Aborted women, IL-6, IL-8, IFN-γ, Parvovirus B19, RhD blood type.
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http://rbmb.net/browse.php?a_code=A-10-749-2&slc_lang=en&sid=1
Dhurgham
Al-Fahad
dhurgham.alfahad@sci.utq.edu.iq.
100319475328460012562
100319475328460012562
Yes
Department of Pathological Analysis, College of Science, University of Thi-Qar,Thi-Qar, Iraq.
Khalid
Majeed
100319475328460012563
100319475328460012563
No
Iraq. 2: Department of Medical Laboratory Technique, Al-Nasiriyah Technical Institute, Southern Technical University, Thi-Qar, Iraq.
Ahmed
Al-Naqshbandi
100319475328460012564
100319475328460012564
No
Department of Laboratory, Rizgary Teaching Hospital, Erbil, Kurdistan Region, F.R. Iraq.
Ahmed
Al-Amery
100319475328460012565
100319475328460012565
No
Department of Physiology, College of Medicine, University of Thi-Qar, Thi-Qar, Iraq.
Bandar
Fahad Alharbi
100319475328460012566
100319475328460012566
No
Department of clinical laboratory, College of Applied Medical Science, University of Hail, Hail, Saudia Arabia.