en زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> Cardiovascular disease is one of the most common causes of morbidity and mortality&nbsp;worldwide. The Proline and Serine Rich Coiled-Coil 1 gene in 1p13.3 locus has been reported to be&nbsp;associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The&nbsp;objective of this study was to investigate the association between the rs599839 polymorphism of the Proline&nbsp;and Serine Rich Coiled-Coil 1 (PSRC1) gene with CVD outcomes in a population sample recruited as part&nbsp;of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort.<br> <br> <strong><em>Methods:</em></strong> Five hundred and nine individuals who had an average follow-up period of 10 years were enrolled&nbsp;as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based&nbsp;method.<br> <br> <strong><em>Results:</em></strong> The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= 4.7; 95%&nbsp;CI, 2.5-8.7; p< 0.001) in comparison to those with AA genotype; however, the result was not significant for&nbsp;GG genotype data.<br> <br> <strong><em>Conclusions: </em></strong>The results suggest that the GA/GG genotypes of the PSRC1gene locus were at increased&nbsp;risk of CVD in a representative population-based cohort, demonstrating further functional analysis to&nbsp;discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.</div> Cardiovascular diseases, cohort studies, Genetic Polymorphism, PSRC1 gene 653 663 http://rbmb.net/browse.php?a_code=A-10-811-1&slc_lang=en&sid=1 Mohammad Sadegh Khorrami 100319475328460012463 100319475328460012463 No Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. Fatemeh Sadabadi 100319475328460012464 100319475328460012464 No Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. Alireza Pasdar 100319475328460012465 100319475328460012465 No Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Hamide Safarian-Bana 100319475328460012466 100319475328460012466 No Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. Forouzan Amerizadeh 100319475328460012467 100319475328460012467 No Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Habibollah Esmaeily 100319475328460012468 100319475328460012468 No Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Department of Epidemiology and Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran. Mohsen Moohebati 100319475328460012469 100319475328460012469 No Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. Alireza Heidari-Bakavoli 100319475328460012470 100319475328460012470 No Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. Gordon Ferns 100319475328460012471 100319475328460012471 No Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK. Majid Ghayour-Mobarhan ghayourm@mums.ac.ir 100319475328460012472 100319475328460012472 Yes Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. Amir Avan 100319475328460012473 100319475328460012473 No Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.