en ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background: </em></strong>During the gathering of demographic data for the biobank on Buerger&rsquo;s Disease (BD), we&nbsp;found that, after the clinical manifestation of BD, the patients usually became infertile, and the age of their&nbsp;last child was compatible with the time of disease diagnosis. The aim of this study was to evaluate the&nbsp;underlying cause of secondary infertility in BD patients.<br> <br> <em><strong>Methods: </strong></em>Anti-sperm antibodies (ASA), testosterone, luteinizing hormone (LH), and follicle-stimulating&nbsp;hormone (FSH) in the sera of 39 male BD patients were measured and compared with 39 age-matched&nbsp;Caucasian male controls.<br> <br> <strong><em>Results:</em></strong> Six patients declared that they suffered from impotency. The ASA level was positive in 25.6% of&nbsp;the patients and 2.4% of the controls (p= 0.003, CC= 6.96). The mean levels of testosterone in the patients&nbsp;and controls were 393.12&plusmn;32.9 ng/dl and 354.37&plusmn;30.9 ng/dl, respectively. The mean levels of LH in the&nbsp;patients and controls were 0.88&plusmn;0.12 mIU/r and 0.85&plusmn;0.1 mIU/r, respectively. The mean levels of FSH in&nbsp;the patients and controls were 4.1&plusmn; 0.35 mIU/r and 3.56&plusmn;0.33 mIU/r, respectively. No significant difference&nbsp;in the serum levels of testosterone, LH, or FSH was found between the patients and controls (p> 0.05). The&nbsp;spermograms of three ASA-negative patients demonstrated impaired sperm motility.&nbsp;<br> <br> <strong><em>Conclusions:</em></strong> Anti-sperm antibodies, disturbed genital circulation, autonomic dysfunction and sperm&nbsp;motility may be responsible for secondary infertility in Buerger&rsquo;s Disease.</div> Anti-sperm antibody, Buerger’s Disease, Infertility, Thromboangiitis Obliterans 246 251 http://rbmb.net/browse.php?a_code=A-10-106-2&slc_lang=en&sid=1 Aghigh Ziaeemehr 100319475328460012197 100319475328460012197 No 1: Cancer Research Center, Mashhad University of medical sciences, Mashhad, Iran & Surgical Oncology Research Center, Mashhad university of medical sciences, Mashhad, Iran. Hiva Sharebiani 100319475328460012198 100319475328460012198 No Immunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hossein Taheri 100319475328460012199 100319475328460012199 No Surgery Department, Farabi Hospital, Mashhad, Iran. Bahare Fazeli fazelib@mums.ac.ir. 100319475328460012200 100319475328460012200 Yes Immunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. & Vascular Independent Research and Education, European Foundation. Milan, Italy.