Reports of Biochemistry and Molecular Biology

en Intrauterine Instillation of Human Chorionic Gonadotropin with Intrauterine Insemination Catheter Around the Golden Time of Embryo Transfer Does Not Improve In Vitro Fertilization /Intracytoplasmic Sperm Injection Outcomes in Infertile Women: A Randomized Controlled Trial بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: We set out to explore the effect of intrauterine human chorionic gonadotropin (hCG) instillation by intrauterine insemination (IUI) catheter before embryo transfer (ET) on assisted reproductive technologies (ART) outcomes of infertile women.  </div> <div style="text-align: justify;">Methods: One hundred women with infertility who were scheduled for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles were included in the study. They were randomly devoted to two groups: experimental (n= 50) and control (n= 50). In the experimental group, 500 IU hCG passed into the internal cervical orifice via IUI catheter within 15 minutes before the transfer of </div> <div style="text-align: justify;">fresh or vitrified cleavage-stage embryos. The control group underwent the same ET procedure without prior injection of hCG.  </div> <div style="text-align: justify;">Results: None of the outcomes showed a statistically significant difference between the two groups. In the intervention and control groups, respectively, biochemical pregnancies rates were 26% and 18%, implantation rates were 13.5% and 8.6%, clinical pregnancies rates were 22% and 14%, ongoing pregnancies rates were 18% and 14%, and live birth rates were 14% and 12%.  </div> <div style="text-align: justify;">Conclusions:Intrauterine injection of hCG via IUI catheter is not recommended in a clinical routine setting at this stage. Future efforts are warranted to further refine the applicability of this modality. </div> <div style="text-align: justify;"></div> Assisted reproductive technologies, Embryo transfer, Human chorionic gonadotropin, Intrauterine insemination catheter, Randomized clinical trial. 358 366 http://rbmb.net/browse.php?a_code=A-10-982-1&slc_lang=en&sid=1 Elham Naghshineh 100319475328460012275 100319475328460012275 No Department of Obstetrics & Gynecology, School of Medicine, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran Reihanah Dehghani Mohammadabadi 100319475328460012276 100319475328460012276 No Department of Obstetrics & Gynecology, School of Medicine, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran Ferdous Mehrabian 100319475328460012277 100319475328460012277 No Department of Obstetrics & Gynecology, School of Medicine, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran Hatav Ghasemi Tehrani hatav.ghasemi@yahoo.com. 100319475328460012278 100319475328460012278 Yes Department of Obstetrics & Gynecology, School of Medicine, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran Mohammad Javad Tarrahi 100319475328460012279 100319475328460012279 No Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.