en زیست شناسی سلولی Cell Biology مقالات اصلی Original Article <div style="text-align: justify;"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">The role of the basic fibroblast growth factor (bFGF) has well known in the angiogenesis and ulcer healing. In this study, we aimed to evaluate the effects of bFGF on tissue repair in a rat oral mucosal wound.</span></span></span></span></span></span><br> <br> <span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Methods:</span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Musosal wound induced on the lip mucosa of rats and bFGF was injected along the edge of the mucosal defect immediately after surgery. The tissues were collected on days 3, 7 and 14 after the wound induction. The micro vessel density (MVD) and CD34 expression were done by histochemical studies.</span></span></span></span></span></span><br> <br> <span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">The bFGF significantly accelerated granulation tissue formation and MVD was increased three days after ulcer induction but decreased 14 days after surgery. The MVD was significantly higher in the bFGF-treated group. The wound area was decreased in all groups time-dependently and a statistically significant difference (p value?) was observed between the bFGF-treated group and untreated group. The wound area was smaller in the bFGF-treated group compared to the untreated group.</span></span></span></span></span></span><br> <br> <span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Conclusions:</span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Our data demonstrated that bFGF can accelerated and facilitated wound healing.</span></span></span></span></span></span></span></div> bFGF, Healing, Angiogenesis, Wound, Micro Vessel Density. 547 552 http://rbmb.net/browse.php?a_code=A-10-1002-1&slc_lang=en&sid=1 Reza Zare 100319475328460016771 100319475328460016771 No Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Hamidreza Abdolsamadi 100319475328460016772 100319475328460016772 No Dental Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Sara Soleimani Asl 100319475328460016773 100319475328460016773 No Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran. Shahrbanoo Radi 100319475328460016774 100319475328460016774 No Department of Oral Medicine, Hamedan University of Medical Sciences, Hamedan, Iran. Hossein Bahrami 100319475328460016775 100319475328460016775 No General Dentist, Private Practice, Hamadan, Iran. Shokoofeh Jamshidi dr.jamshidi39@gmail.com. 100319475328460016776 100319475328460016776 Yes Department of Oral and Maxillofacial Pathology, School of Dentistry, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.