en بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.3pt">Background:</span></span></span></i></b><b><i> </i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.3pt">The Transforming Growth Factor-beta (TGF-&beta;) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role in hepatocarcinogenesis is controversial.<b><i> </i></b>To highlight the role of Transforming Growth Factor &beta; as a marker of Hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus (HCV) infection.</span></span></span></span></span></span></span><br> <br> <span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.3pt">Methods:</span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.3pt">Ninety subjects were enrolled in this study, classified into three groups: Group I (chronic HCV group) included 30 patients with chronic HCV infection; Group II (HCC group) include 30 patients having HCC and chronic HCV infection and Group III consisted of 30 age and sex-matched healthy controls. TGF-&beta; was evaluated in all the enrollees and its levels were correlated to liver function and other clinical parameters.</span></span></span></span></span></span></span><br> <br> <span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.3pt">Results:</span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.3pt">TGF-&beta; was found significantly higher in HCC group than in control and chronic HCV (P <0.001). In addition, it was correlated with biochemical and clinical parameters of cancer.</span></span></span><br> <span lang="EN-ID" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.3pt"></span></span></span></span></span></span></span><br> <span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.3pt">Conclusions:</span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.3pt">Patients with HCC showed increased level of TGF-&beta; compared to chronic HCV infection patients and controls.</span></span></span></span></span></span></span></div> Chronic HCV, Liver cirrhosis, Transforming Growth Factor β. 702 709 http://rbmb.net/browse.php?a_code=A-10-1039-1&slc_lang=en&sid=1 Assem Abdeen Radwan eltabeeb84@gmail.com. 100319475328460016864 100319475328460016864 Yes Department of Internal Medicine, Faculty of Medicine, Aswan University, Egypt. Nour El-Dean Abd-Elazeem Hefney 100319475328460016865 100319475328460016865 No Department of Internal Medicine, Faculty of Medicine, Assuit University, Egypt. Emad Farah Mohammed Kholef 100319475328460016866 100319475328460016866 No Department of Clinical Pathology, Faculty of Medicine, Aswan University, Egypt. Abdallah Elebidi 100319475328460016867 100319475328460016867 No Department of Medical Biochemistry, Faculty of Medicine, Aswan University, Egypt. Hala Mahmoud 100319475328460016868 100319475328460016868 No Department of Internal Medicine, Faculty of Medicine, Aswan University, Egypt.