en ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.3pt">Background:</span></span></span></span></i></b>&nbsp;&nbsp;</span></span></span></span></span></span><span style="font-size:12.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.3pt">Allergic</span></span></span></span></span><span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.3pt">rhinitis (AR) is an inflammatory disorder of the nasal mucosa, caused by exposure to environmental allergens. It is known that 15-lipoxygenase (15-LOX) is involved in the biosynthetic pathways of anti-inflammatory lipid mediators, including resolvins and protectins. </span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.3pt">Methods:</span></span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.3pt">In this study, which was performed on 130 AR patients and 130 healthy controls, we aimed to investigate the association of susceptibility to AR with two selected single-nucleotide polymorphisms (SNPs), that is, rs2619112:A>G and rs7217186:C>T, in the intron regions of arachidonic acid 15-LOX (<i>ALOX15</i>) gene, using SNPinfo and Regulome DB tools.</span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.3pt">Results:</span></span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.3pt">The results showed that the CT genotype of rs7217186: C>T was significantly associated with the increased risk of AR compared to the CC genotype (<i>P</i>= 0.037, OR=1.943, CI: 1.038-0.638). However, there was no strong evidence of the association of rs2619112: A>G with susceptibility to AR (<i>P</i>> 0.05).</span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.3pt">Conclusions:</span></span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.3pt">The present results indicated that rs7217186 polymorphism of <i>ALOX15</i> gene might be a potential biomarker for susceptibility to AR.</span></span></span></span></span></span></span></span></span></span></div> Allergic rhinitis, Arachidonate 15-lipoxygenase, Immunoresolvents, Single-nucleotide polymorphism, Specialized proresolving lipid mediators (SPMs). 269 276 http://rbmb.net/browse.php?a_code=A-10-556-3&slc_lang=en&sid=1 Atefeh Eivazi 100319475328460017940 100319475328460017940 No Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Bahman Akbari 100319475328460017941 100319475328460017941 No Department of Biotechnology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Sara Falahi 100319475328460017942 100319475328460017942 No Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Ali Gorgin Karaji 100319475328460017943 100319475328460017943 No Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Alireza Rezaiemanesh 100319475328460017944 100319475328460017944 No Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Seyed Hamid Reza Mortazavi 100319475328460017945 100319475328460017945 No Department of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Niloofar Daneshfar 100319475328460017946 100319475328460017946 No Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Farhad Salari .salari@kums.ac.ir 100319475328460017947 100319475328460017947 Yes Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.