Reports of Biochemistry and Molecular Biology

en Association of Body Mass Index with Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Interleukin-6 Based on Blood Pressure زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;">Background: high body mass index (BMI) is known to be associated with high blood pressure. Levels of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and interleukin-6 (IL-6) are also increased in hypertensive patients. The aim of this study was to determine the correlation of BMI with MMP-9, TIMP-1, and IL-6 based on blood pressure. Methods: The study design was cross-sectional with subjects aged >= 36 years, male and female and divided into 3 groups: group with normal blood pressure (NBP), group with controlled hypertension (CHT), and group with uncontrolled hypertension (UcHT). Height, weight, and blood pressure were measured, as well as serum levels of MMP-9, TIMP-1 and IL-6 using the ELISA method. The correlation was considered significant at p-value of < 0.05. Result: The BMI in group UcHT was higher than in the other groups. THERE was a positive correlation between BMI and MMP-9; BMI and TIMP-1; and BMI and IL-6 (r=0.480, p=0.007; r=0.620; p=0.000; r=374, p=0.042 respectively) in group UcHT. Conclusions: An increase in BMI is accompanied by an increase in levels of MMP-9, TIMP-1, and IL-6 in group UcHT, signifying that it is necessary to control BMI to maintain stable levels of MMP-9, TIMP-1, and IL-6, thereby keeping blood pressure under control.</div> Body mass index (BMI), Blood pressure, Interleukin-6 (IL-6), Matrix metalloproteinase-9 (MMP-9), Tissue inhibitor of metalloproteinase-1 (TIMP-1) 137 143 http://rbmb.net/browse.php?a_code=A-10-1478-1&slc_lang=en&sid=1 Tjam Diana Samara dianasamara@trisakti.ac.id 100319475328460020346 100319475328460020346 Yes Department of Anatomy, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia. Magdalena Wartono 100319475328460020347 100319475328460020347 No Department of Anatomy, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia. Adrianus Kosasih 100319475328460020348 100319475328460020348 No Department of Internal Medicine, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia. Alvina Alvina 100319475328460020349 100319475328460020349 No Department of Clinical Pathology, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia & Laboratory of Sumber Waras Hospital, Jakarta, Indonesia.