en بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">Background:</span></span></span></span></i></b><b><i> </i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">X-ray exposure can result in acute or chronic damage to lung tissue, leading to pneumonitis<b> </b>and fibrosis. Given the potent antioxidant properties of sumac, this study investigates the impact of hydroalcoholic sumac extract on X-ray-induced pulmonary fibrosis in rats.</span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">Methods:</span></span></span></span></i></b><b> </b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">In this experimental study, 36 rats were randomly divided into six groups of six rats each. The treatment and sham groups received intraperitoneal administration of the extract daily for one week before exposure to X-ray radiation. On the seventh day, all rats except those in group 3 were exposed to 2 Gy of 6 MV X-rays using an electro-linear accelerator. Lung tissue was subsequently removed to assess the subacute effects of the extract. Data analysis involved independent sample t-tests and one-way ANOVA using SPSS 26.</span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">Results:</span></span></span></span></i></b><b> </b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">A single dose of X-rays significantly increased oxidative stress and lung tissue damage in rats. However, rats receiving vitamin C and hydroalcoholic sumac extract at two different doses (100 and 400 mg/kg intraperitoneally) positively improved lung damage and decreased antioxidant parameters.</span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">Conclusion:</span></span></span></span></i></b><b> </b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">The findings demonstrate that hydroalcoholic sumac extract can mitigate oxidative stress and enhance lung repair following X-ray radiation exposure.</span></span></span></span></span></span></span></span></span></span></div> Antioxidant, CT X-Ray, Pulmonary Fibrosis, Radiation protective agents. 231 242 http://rbmb.net/browse.php?a_code=A-10-1489-2&slc_lang=en&sid=1 Faezeh Rezaie 100319475328460020413 100319475328460020413 Yes Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran. Aboulfazl Ghafouri Khosroshahi 100319475328460020414 100319475328460020414 No Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran. Amir Larki-Harchegani 100319475328460020415 100319475328460020415 No Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran. Alireza Nourian 100319475328460020416 100319475328460020416 No Department of Pathobiology, School of Veterinary Science, Bu-Ali Sina University, Hamadan, Iran. Hossein Khosravi h.khosravi@umsha.ac.ir. 100319475328460020417 100319475328460020417 No Department of Radiology, School of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.