en بیوشیمی Biochemistry مقالات مروری Review <div style="text-align: justify;"><strong><em>Background:</em></strong> Pre-eclampsia (PE) is a pregnancy disorder characterized by hypertension and proteinuria. The evidence has suggested that microRNAs (miRs) are associated with pre-eclampsia pathogenesis; however, these results are inconsistent. The aim of this study was to assess the association between miR-210 expression and PE risk.<br> <br> <strong><em>Methods:</em></strong> Previous studies were selected using PubMed, Scopus, MEDLINE, EMBASE, Science Direct, Google Scholar, Directory of Open Access Journals (DOAJ), and Scientific Information Database (SID). This meta-analysis includes 12 studies associated with miR-210 and pre-eclampsia and necessary information was extracted.<br> &nbsp;&nbsp;<br> <strong><em>Results:</em></strong> The standardized mean differences [(SMD (0.32) 95% CI (014&ndash;0.49), p=0.97] and heterogeneity were determined with the chi-square test (Q=3.63 df =11 p= 0.97), which found no heterogeneity between these studies. Additionally, publication bias was evaluated by Egger&rsquo;s and Begg&acute;s tests. Visual inspection of the funnel plot graphically, and statistically with Egger&rsquo;s weighted regression [(p= 0.35) (95% CI -0.90 &ndash; 2.29)] and Begg&rsquo;s rank correlation (p= 0.21), found no important publication bias between studies within the meta-analysis.<br> <br> <strong><em>Conclusions:</em></strong> Our findings suggest that miR-210 contributes to the pathogenesis of PE; therefore, miR-210 could serve as a novel biomarker to predict PE pathophysiology. Further studies are required in this field to characterize the mechanism involved in this process.</div> Meta-analysis, MiR-210, Pre-eclampsia 94 101 http://rbmb.net/browse.php?a_code=A-10-127-1&slc_lang=en&sid=1 Mehdi Koushki Mehdikoushki89@gmail.com 10031947532846006397 10031947532846006397 No Biochemistry Department, Medicine Faculty, Tehran University of Medical Sciences, Tehran Nasrin Amiri Dash Atan nasrinamiri91@gmail.com 10031947532846006398 10031947532846006398 No Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hossein Omidi-Ardali 10031947532846006399 10031947532846006399 No Mostafa Rezaei Tavirani tavirany@yahoo.com 10031947532846006400 10031947532846006400 Yes Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.