en زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> Cardiovascular disease (CVD) is a leading cause of death, supporting the need for the identification of novel biomarkers as risk stratification factors. Endonuclease G (ENDOG) has recently been suggested to be a novel determinant of cardiac hypertrophy and mitochondrial function, and plays an important role in apoptosis processes involved in cardiac myocyte death. The aim of current study was to explore the association of two genetic variants in ENDOG gene (<em>ENDOG</em>) with CVD risk factors in an Iranian population.<br> <strong><em>Methods:</em></strong> Subjects included 663 patients with CVD and 282 healthy individuals recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders Cohort Study. The <em>ENDOG</em> S12L (rs 2293969) and L142M (rs 61397314) variants were genotyped. Anthropometric and biochemical factors were measured in all the subjects followed by univariate and multivariate analyses to determine the association of these genetic markers with CVD and biochemical parameters.<br> <strong><em>Results:</em></strong> &nbsp;<em>ENDOG</em> polymorphisms were found at a significantly higher prevalence in individuals who had histories of smoking and breaking point in L142M. In contrast, other risk factors for cardiovascular disease, including lipid profile and blood pressure, showed no or very weak relationship with the <em>ENDOG</em> polymorphisms.<br> <strong><em>Conclusions:</em></strong> Our findings indicated an association between an <em>ENDOG</em> genetic variant and smoking history as a cardiovascular risk factor. Further studies in the prospective setting are warranted to investigate the value of this marker.<br> &nbsp;</div> Cardiac Vascular Diseases, Endonuclease G, Polymorphism. 147 152 http://rbmb.net/browse.php?a_code=A-10-95-3&slc_lang=en&sid=1 Negar Etehad Roodi negar.etehad@yahoo.com 100319475328460017314 100319475328460017314 No Cellular and Molecular Research Centre, Iran University of Medical Science, Tehran, Iran. Nushin Karkuki Osguei osguei@yahoo.com 100319475328460017315 100319475328460017315 No Eposcience Millennium Institute, Tehran, Iran. Mahdy Hasanzadeh Daloee hasanzadeh@yahoo.com 100319475328460017316 100319475328460017316 No Cardiovascular Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Alireza Pasdar pasdar@yahoo.com 100319475328460017317 100319475328460017317 No Molecular Medicine Group, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Majid Ghayour-Mobarhan gh.mobarhan@yahoo.com 100319475328460017318 100319475328460017318 No Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Gordon Ferns 100319475328460017319 100319475328460017319 No Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK. Ali Samadi Kuchaksaraei samadikuchaksaraei@yahoo.com 100319475328460017320 100319475328460017320 Yes Cellular and Molecular Research Centre, Iran University of Medical Science, Tehran, Iran.