en زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> The enzyme beta-secretase 1 (BACE1) and its antisense transcript (<em>BACE1-AS</em>) have been implicated in the pathogenesis of Alzheimer&#39;s disease. Moreover, several lines of evidence point to their contribution in tumorigenesis.<br> <br> <strong><em>Methods:</em></strong> In the present study, we evaluated expression of BACE1 mRNA (<em>BACE1)</em> and <em>BACE1-AS</em> in 54 breast cancer tissues and 54 adjacent non-cancerous tissues (ANCTs) from the same patients using quantitative real-time PCR.<br> <br> <strong><em>Results:</em></strong> <em>BACE1</em> was significantly down-regulated in tumoral tissues compared with ANCTs, while <em>BACE1-AS</em> expression was not significantly different between tumoral tissues and ANCTs. The Bayesian Multilevel model showed a significant difference in <em>BACE1</em> expression between stage 1 and 2 cancers after age-effect adjustments. <em>BACE1-AS</em> expression was significantly greater in ER-positive than in ER-negative samples (P=0.01). <em>BACE1</em> and <em>BACE1-AS</em> expression were not correlated with patient ages in any sample sets.<br> <br> <strong><em>Conclusions:</em></strong> Significant correlations were detected between expression of these genes in both tumoral tissues and ANCTs. The current study provides evidence for differential <em>BACE1 </em>expression in breast tissues and suggests further assessment of the role of <em>BACE1</em> in the pathogenesis of cancer.<br> &nbsp;</div> BACE1, BACE1-AS, Breast Cancer, Lncrna. 200 207 http://rbmb.net/browse.php?a_code=A-10-187-5&slc_lang=en&sid=1 Hajar Yaghoobi hajar_yaghobi@yahoo.com 100319475328460017298 100319475328460017298 No University of Medical Sciences, Shahrekord, Iran. & Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran. Hakim Azizi hakimazizi190@yahoo.com 100319475328460017299 100319475328460017299 No Department of Medical Parasitology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran. Mehdi Banitalebi-Dehkordi banitalebi@yahoo.com 100319475328460017300 100319475328460017300 No University of Medical Sciences, Shahrekord, Iran. Fatemeh Mohammad Rezaei f_m.rezaei@yahoo.com 100319475328460017301 100319475328460017301 No Department of Medical Genetic, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Shahram Arsang-Jnag shahramarsang@gmail.com 100319475328460017302 100319475328460017302 No Clinical Research Development Center (CRDU), Qom University of Medical Sciences, Qom, Iran. Mohammad Taheri mohammad_823@yahoo.com 100319475328460017303 100319475328460017303 Yes Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Soudeh Ghafouri-Fard s.ghafourifard@sbmu.ac.ir 100319475328460017304 100319475328460017304 No Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.