en زیست شناسی سلولی Cell Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> Breast cancer is classified as one of the common cancers among women worldwide. Within numerous genetic factors involved in the development of breast cancer, <em>lsp1</em> and <em>casc</em> genes are both located on breast cancer susceptibility locus. While the SNP <em>rs3817198</em> in <em>lsp1</em> gene has a twilight association with breast cancer in different populations, <em>casc</em> <em>rs4784227</em> polymorphisms have been reported to associate with breast tumor appearance in Asian, European, and African ancestry populations. The present report was designed a case-control group aimed at assessing the association of these two SNPs with breast cancer risk in the Iranian population.<br> <br> <strong><em>Methods:</em></strong> In the case-control study of <em>rs3817198</em> and <em>rs4784227</em> polymorphisms in 100 women with breast cancer and 100 healthy women were examined by Tetra Arms PCR. Data collected using SPSS software and chi-square test and correlation coefficient were used for statistical analysis.<br> <br> <strong><em>Results:</em></strong> The results of current study showed that the Chi-square of <em>lsp1</em> <em>rs3817198</em> and <em>casc</em> <em>rs4784227 </em>polymorphism genotypes in breast cancer, were reported to be 51.613 and 47.920, respectively. Also there has been a significance level of both polymorphisms resulting in the frequency of genotypes in these two polymorphisms between case and control group.<br> <br> <strong><em>Conclusions:</em></strong> Our finding thus suggested that in both polymorphisms, homozygote genotype showed strong correlation with cancer susceptibility. While, TT genotype in <em>lsp1</em> <em>rs3817198</em> showed significant association with pathogenic properties, in the case of <em>casc</em> <em>rs4784227</em> genotypes CC, and in second place, TT showed similar correlation.</div> Breast cancer, Casc, Lsp1, Polymorphism 291 296 http://rbmb.net/browse.php?a_code=A-10-400-1&slc_lang=en&sid=1 Zahra Nourolahzadeh 100319475328460017663 100319475328460017663 No Department of Molecular Biology, Ahar Branch Islamic Azad University, Ahar, Iran Seyyed Masoud Houshmand Housh62@yahoo.com 100319475328460017664 100319475328460017664 Yes Department of Molecular Biology, Ahar Branch Islamic Azad University, Ahar, Iran & Knowledge University, Erbil Kurdistan region, Iraq. Fawzia Mostafa Mohammad 100319475328460017665 100319475328460017665 No Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait. Saeed Ghorbian 100319475328460017666 100319475328460017666 No Department of Molecular Biology, Ahar Branch Islamic Azad University, Ahar, Iran