en بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;"><em><strong>Background:</strong> </em>Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally, and specifically in Iran. Generally, diabetes mellitus is the result of impaired glucose tolerance which together with dyslipidemia are considered as important risk factors of CVD. The aim of this study was to determine the relationship between fasting serum glucose (FSG), lipid profile and CVD endpoints, and to establish an optimal FSG cut-off in the MASHAD cohort study after nearly 6 years of follow-up.<br> <em><strong>Methods:</strong></em> All the participants of MASHAD study were followed up for 6 years to determine their cardiovascular status. FSG, fasting lipids, and physical examinations were all recorded. To identify the optimal cut- off point of FSG, we carried out receiver operating curve (ROC) analysis<br> <strong><em>Results:</em></strong> We determined MASHAD cutoff point of blood glucose as 90 mg/dl predicting the CVD outcome. The sensitivity and specificity of the FSG criterion were 54.34% and 71.68%, respectively. The AUC was 0.665 (95% CI 0.656-0.675, P< 0.0001). The adjusted hazard ratio show that FSG is associated with 2.34 increase in CVD risk using MASHAD cutoff point (HR 2.34, 95% 1.73&ndash;3.17, P< 0.001).<br> <strong><em>Conclusions:</em></strong> These findings suggest that not only FSG and lipid profile are related to CVD outcome in the MASHAD study, but also elevated fasting glucose levels is strongly associated with cardiovascular events in this population. Besides, the fasting glucose at a threshold of 90 mg/dl can be used for screening cardiovascular events among the Iranian population.</div> Fasting Serum Glucose, Lipid profile, Cardiovascular disease (CVD), MASHAD cohort study. 64 70 http://rbmb.net/browse.php?a_code=A-10-266-2&slc_lang=en&sid=1 Fatemeh Sadabadi Sadabadif2@mums.ac.ir 100319475328460017512 100319475328460017512 No Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Aida Gholoobi Gholoubiad@mums.ac.ir 100319475328460017513 100319475328460017513 No Medical Genetics Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Alireza Heidari-Bakavol 100319475328460017514 100319475328460017514 No Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mohsen Mouhebati 100319475328460017515 100319475328460017515 No Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Ali Javandoost 100319475328460017516 100319475328460017516 No Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Zahra Asadi 100319475328460017517 100319475328460017517 No Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Maryam Saberi-Karimian 100319475328460017518 100319475328460017518 No Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Susan Darroudi 100319475328460017519 100319475328460017519 No Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mohammad Sadegh Khorrami Mohebbseraj 100319475328460017520 100319475328460017520 No Department of Medical Genetic and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Farzad Rahmani 100319475328460017521 100319475328460017521 No Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Najmeh Malekzadeh Gonabadi 100319475328460017522 100319475328460017522 No Department of genetic, School of science, Sistan and Baluchestan University, Zahedan, Iran. Fatemehalsadat Jafari Sheshtamad 100319475328460017523 100319475328460017523 No Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Sara Samadi 100319475328460017524 100319475328460017524 No Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Afsane Bahrami 100319475328460017525 100319475328460017525 No Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran. Gordon Ferns 100319475328460017526 100319475328460017526 No Department of Medical Education, Brighton & Sussex Medical School, Brighton, BN1 9PH, UK Majid Ghayour-Mobarhan 100319475328460017527 100319475328460017527 No Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. & International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Habibollah Esmaeili 100319475328460017528 100319475328460017528 Yes Department of Biostatistics & Epidemiology, School of Health, Management & Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.