en زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong>Background: </strong>Multiple sclerosis (MS) is a common demyelinating neurodegenerative disorder with significant heritability. Previous studies have associated genetic variants in human leukocyte antigen (<em>HLA</em>) complex, <em>IL2RA</em>, and <em>HMGB1 </em>genes with the pathophysiology of MS.<br> <br> <strong>Methods</strong>: In order to investigate the gene association in the Iranian population, we performed a genotyping study of 36 variants in the mentioned genes using Sanger sequencing in 102 MS patients and 113 healthy controls.<br> <br> <strong>Results: </strong>Our results identified significant associations as well as significant allele frequency differences in some of the studied single-nucleotide polymorphisms including rs4935356, rs3177928, and rs7197 from <em>HLA-DRA </em>gene, and rs12722489 and rs12722490 variants from <em>IL2RA</em> gene (<em>p</em>< 0.05). Moreover, the strong linkage disequilibrium of two common haplotypes was estimated from the <em>HLA-DRA</em> gene.<br> <br> <strong>Conclusions: </strong>This association study may suggest the role of these polymorphisms in the genetic susceptibility of MS in the Iranian population and would facilitate the recognition of causative variants in this disease.</div> HMGB1, HLA-DRA, IL2RA, Multiple sclerosis, Polymorphism 199 208 http://rbmb.net/browse.php?a_code=A-10-425-2&slc_lang=en&sid=1 Mohsen Asouri 100319475328460017603 100319475328460017603 No Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran & North Research Center, Pasteur Institute of Iran, Amol, Iran. hamid Alinejad Rokni 100319475328460017604 100319475328460017604 No Systems Biology and Health Data Analytics Lab, the Graduate School of Biomedical Engineering, UNSW Sydney, 2052, NSW, AU Mohammad Ali Sahraian 100319475328460017605 100319475328460017605 No Multiple Sclerosis Research Center; Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Sadegh Fattahi 100319475328460017606 100319475328460017606 No North Research Center, Pasteur Institute of Iran, Amol, Iran Nima Motamed 100319475328460017607 100319475328460017607 No Department of Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Rozita Doosti 100319475328460017608 100319475328460017608 No Multiple Sclerosis Research Center; Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Hamzeh Rahimi 100319475328460017609 100319475328460017609 No Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Maryam Lotfi 100319475328460017610 100319475328460017610 No North Research Center, Pasteur Institute of Iran, Amol, Iran Azam Moslemi 100319475328460017611 100319475328460017611 No Department of Biostatistics, Faculty of Medical Sciences, Arak University of Medical Sciences, Arak, Iran Morteza Karimpoor mortezakarimi@pasteur.ac.ir 100319475328460017612 100319475328460017612 No Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Fereidoun Mahboudi mahboudi@pasteur.ac.ir 100319475328460017613 100319475328460017613 Yes Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Haleh Akhavan-Niaki halehakhavan@yahoo.com 100319475328460017614 100319475328460017614 No Zoonoses Research Center, North Research Center, Pasteur Institute of Iran, Amol, Iran & Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran