en زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div><strong><em>Background:</em></strong> We aimed to evaluate the effectiveness of Highly Upregulated in Liver Cancer (HULC) and microRNA-372 (miR-372) as biochemical markers in Hepatocellular carcinoma (HCC) and HCV-infected patients.<br> <br> <strong><em>Methods:</em></strong> The present study was conducted on 100 Egyptian individuals divided into 3 groups, 40 patients with HCC and HCV infection, 40 patients only HCV-infected, and 20 individuals as normal controls. They were subject to full history taking, full clinical and laboratory examination, and assessment of HULC and miR-372 levels by real-time PCR.<br> <br> <strong><em>Results:</em></strong> A statistically significant difference was found with <em>p</em>< 0.05 between HCC and each of HCV and control groups as regards HULC level with high mean among HCC followed by HCV patients. Our results also show a statistically significant difference with <em>p</em>< 0.05 between each of HCC and HCV compared to control as regards miR-372 level with low mean among HCC patients.<br> <br> <strong><em>Conclusions:</em></strong> HULC could be considered as a potential non-invasive marker for detection and early diagnosis of HCC. Also, it may play an important role in the early prophylaxis and control measures to reduce the incidence of HCC<strong><em>.</em></strong> However, miR-372 cannot be considered as a reliable marker as HULC for early detection of HCC especially in HCV patients.<strong><span dir="RTL"></span></strong></div> HCC, HCV, HULC, MiRNA-372 230 240 http://rbmb.net/browse.php?a_code=A-10-519-1&slc_lang=en&sid=1 Olfat Shaker 100319475328460017630 100319475328460017630 No Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Egypt Hala Mahfouz halaelsaid111@gmail.com 100319475328460017631 100319475328460017631 Yes Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Kafrelsheikh University, Egypt Ahmad Salama 100319475328460017632 100319475328460017632 No Tropical Medicine Department, Faculty of Medicine, Cairo University, Egypt Engy Medhat 100319475328460017633 100319475328460017633 No Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Egypt