en ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> The precise responsible mechanism of pre-eclampsia remains controversial however, recent data suggest a main role of the abnormal activation of the adaptive immune system and Apoptosis. In this study, we have measured serum levels of Fas/Fasl as two important members of extrinsic apoptotic pathway in patient with pre-eclampsia.<br> <br> <strong><em>Methods:</em></strong>&nbsp;207 participants including 99 pre-eclampsia patients and 108 age and sex-matched normal pregnant women were involved in the case-control study. Plasma sample from each participant was collected and stored at &ndash;20 ̊C until batch processing.<br> Serum levels of Fas and Fas ligand were measured by ELISA for each participant including 99 pre-eclampsia patients and 108 normal pregnant women. Following a test of statistical normality, nonparametric data were analyzed by Mann-Whitney.<br> <br> <strong><em>Results:</em></strong> sFas levels in case group was significantly higher than controls; 584 (397-892) pg/ml in cases opposed to 341 (213-602) pg/ml in controls (p value< 0.01). sFasL in pre-eclampsia women was a little lower than controls; 255 (173-318) pg/ml and in case group compared to 265.5 (184-381.5) pg/ml in controls.<br> <br> <strong><em>Conclusions:</em></strong> We have found the increased levels of sFas in patients with pre-eclampsia in compare with the healthy pregnant women. It seems that abnormality in sFAS is related with pre-eclampsia.</div> Pre-eclampsia, Pregnancy, sFAS, sFASL, Apoptosis. 394 398 http://rbmb.net/browse.php?a_code=A-10-529-1&slc_lang=en&sid=1 Elham Masoumi 100319475328460017723 100319475328460017723 No Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran & Research Committee, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Asad Mirzaei 100319475328460017724 100319475328460017724 No Parasitology department, paramedical school, Ilam University of Medical Science, Ilam, Iran & Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran. Haniyeh Ghaffari-Nazari 100319475328460017725 100319475328460017725 No Immunogenetic and Tissue Culture Department, Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Sahar Tahaghoghi-Hajghorbani 100319475328460017726 100319475328460017726 No Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran & Department of Immunology, School of Medicine, Mazandaran University of Medical Science, Sari, Iran. Seyed Amir jalali jalalia@sbum.ac.ir 100319475328460017727 100319475328460017727 Yes Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Jalil Tavakkol-Afshari* tavakolja@mums.ac.ir 100319475328460017728 100319475328460017728 No Immunogenetic and Tissue Culture Department, Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.