en تخصصي Special <p style="text-align: justify;"><em><strong>Background: </strong></em>Transforming growth factor-&beta;1 (TGF-&beta;1) has been found to play a crucial role in early central nervous system development. Several studies have illustrated decreased TGF-&beta;1 levels in sera and brains of autistic children. Two point mutations in the TGF-&beta;1 signal peptide at 869T/C and 915G/C have been reported to influence TGF-&beta;1 expression. The aim of the present study was to investigate the correlation of TGF-&beta;1 polymorphisms and their haplotypes with autism.</p> <p style="text-align: justify;"><em><strong>Methods:</strong></em> This study was performed on 39 autistic patients and 35 age- and sex-matched normal controls in an Iranian population, using the sequence specific primed-polymerase chain reaction (PCR-SSP) technique. Patients were divided into mild-to-moderate and severe groups according to the childhood autism rating scale.</p> <p style="text-align: justify;"><em><strong>Results:</strong></em> No significant differences were observed for allele, genotype, or haplotype frequencies between the autistics and controls. Only a slight difference was observed in GC25 between the controls and all children with autism.</p> <p style="text-align: justify;"><em><strong>Conclusion:</strong></em> Thus, these results indicate that the polymorphisms in TGF-&beta;1 gene may not play an important role in the development of autism.</p> Autism spectrum disorders, Development, Polymorphism, Transforming Growth Factor beta 1 82 88 http://rbmb.net/browse.php?a_code=A-10-1-42&slc_lang=en&sid=1 Mohammad Reza Khakzad mr.khakzad@gmail.com 10031947532846006067 10031947532846006067 Yes Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran - Department of Immunology, Mashhad Branch, Islamic Azad University, Mashhad, Iran Farhad Salari 10031947532846006068 10031947532846006068 No Immunology Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Javanbakht 10031947532846006069 10031947532846006069 No Department of Psychiatrics, Islamic Azad University, Mashhad Branch, Mashhad, Iran Maryam Hojati 10031947532846006070 10031947532846006070 No Noor Hedayat Center of Autism Spectrum Disorders, Mashhad, Iran Abdolreza Varasteh 10031947532846006071 10031947532846006071 No Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mojtaba Sankian 10031947532846006072 10031947532846006072 No Immunology Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran Mojtaba Meshkat 10031947532846006073 10031947532846006073 No Department of Biostatistc, Shahid Beheshti University of medical sciences, Tehran, Iran