en زیست شناسی سلولی Cell Biology گزارش مورد Case Report <div style="text-align: justify;"><strong><em>Background:</em></strong> Genome-wide association studies (GWAS) have been the primary tool for an unbiased study&nbsp;of the genetic background of coronary artery disease (CAD). They have identified a list of single-nucleotide&nbsp;polymorphisms (SNPs) associated with coronary artery disease (CAD). In this study, we aimed to replicate&nbsp;the association of rs2954029 and rs6982502, a GWAS identified SNP, to CAD in an Iranian population.<br> <br> <strong><em>Methods: </em></strong>A sample of 285 subjects undergoing coronary angiography, including 134 CAD patients&nbsp;and 151 healthy. The genotype determination of rs2954029 and rs6982502 SNPs performed using the&nbsp;high-resolution melting analysis (HRM) technique.&nbsp;<br> <br> <strong><em>Results:</em></strong> Our results revealed that the TT genotype of rs2954029 (p= 0.009) and rs6982502 (p< 0.001)&nbsp;were significantly higher in CAD patients compared with controls. Binary logistic regression showed that&nbsp;rs6982502 and rs2954029 increase the risk of CAD incidence (2.470 times, p= 0.011, 95% CI= [1.219-4.751], and 2.174 times, p= 0.033, 95% CI= [1.066-4.433] respectively). After adjusting for confounders,&nbsp;we found that rs6982502 and rs2954029 are significantly associated with CAD risk.<br> <br> <strong><em>Conclusions</em></strong>: These data showed that the TT genotype of rs2954029 and rs6982502 is associated&nbsp;with the risk of CAD in a hospital-based sample of the Iranian population, which has replicated the&nbsp;result of recent GWAS studies.</div> Coronary Artery Disease (CAD), Genome-Wide Association Studies (GWAS), High-Resolution Melting (HRM), Single-Nucleotide Polymorphisms (SNP). 580 588 http://rbmb.net/browse.php?a_code=A-10-399-2&slc_lang=en&sid=1 Zahereh Karimi 100319475328460012424 100319475328460012424 No Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Javad Daneshmoghadam 100319475328460012425 100319475328460012425 No Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hamid Ghaedi 100319475328460012426 100319475328460012426 No Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Ehsan Khalili 100319475328460012427 100319475328460012427 No Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Ghodratollah Panahi shanaki_m@sbmu.ac.ir. 100319475328460012428 100319475328460012428 Yes Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Mehrnoosh Shanaki* shanaki_m@sbmu.ac.ir. 100319475328460012429 100319475328460012429 No Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.