en بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> Chronic kidney disease (CKD), is a major public health challenge worldwide. It is more&nbsp;prevalent in developed countries compared with the rest of the world, due to the higher rates of life&nbsp;expectancy and unhealthy lifestyle related factors. This aim of the current study is to evaluate the relationship&nbsp;between interleukins IL-2 and IL-17 concentrations and kidney function markers in men with CKD.<br> <br> <em><strong>Methods:</strong></em> Forty-five men with CKD and seventy controls were enrolled in the current study to assess the&nbsp;relationship between interleukin-2 (IL-2), interleukin-17 (IL-17), and CKD parameters. Fasting blood&nbsp;samples were collected from patients with CKD and their controls at same time. Serum IL-2, and IL-17&nbsp;were measured in patients with CKD and their controls, and then the relationship between these interleukins&nbsp;and serum creatinine, serum urea, serum uric acid and urine albumin were evaluated.<br> <br> <strong><em>Results:</em></strong> A significant relationship was detected between IL-2 (p< 0.001), IL-17 (p< 0.001) levels and serum&nbsp;creatinine concentrations. The significant increase of IL-2 and IL-17 levels were also paralleled with a&nbsp;significant increase in serum urea (p< 0.001), and urine albumin (p< 0.001) concentrations respectively.<br> <br> <strong><em>Conclusions:</em></strong> IL-2 and IL-17 may play a critical role in the pathophysiology of CKD. The significant&nbsp;increase of IL-2 and IL-17 is associated with significantly high concentrations of creatinine, serum urea&nbsp;and urine albumin suggesting that these interleukins may be used as targets for future biomarkers and&nbsp;molecular therapy. However, due to limited sample size of the current study, larger prospective cohorts&nbsp;are needed to confirm these observations.</div> Chronic kidney disease, Interleukins, Serum creatinine, Serum urea, Urine albumin. 664 674 http://rbmb.net/browse.php?a_code=A-10-838-1&slc_lang=en&sid=1 Khalid Farouq Al-rawi 100319475328460012474 100319475328460012474 No Department of Chemistry, College of Science, University of Anbar, Al-anbar Province, Iraq. Hameed Hussein Ali 100319475328460012475 100319475328460012475 No Department of Chemistry, College of Science, University of Anbar, Al-anbar Province, Iraq. Manaf Abdulrahman Guma 100319475328460012476 100319475328460012476 No Department of Applied Chemistry, College of Applied Sciences, University of Anbar, Al-anbar Province, Iraq. Bilal Jasir Mohammed Aldahham 100319475328460012477 100319475328460012477 No Department of Applied Chemistry, College of Applied Sciences, University of Anbar, Al-anbar Province, Iraq. Shakir Faris Tuleab Alaaraji 100319475328460012478 100319475328460012478 No Department of Chemistry, College of Education for pure Science, University of Anbar, Al-anbar Province, Iraq. Osamah Al-ani 100319475328460012479 100319475328460012479 No Yarmouk Academic Hospital, Baghdad, Iraq. Aus Tariq Ali drali@europe.com. 100319475328460012480 100319475328460012480 Yes University of Anbar, Al-anbar Province, Iraq.