en بیوشیمی Biochemistry <p style="text-align: justify;"><em><strong>Background:</strong></em> Considerable evidence suggests that oxidative stress affects diabetes mellitus (DM) and contributes to its complications. Vitamin D has been shown to possess antioxidant properties. The aim of this study was to determine the association between serum levels of calcifediol (25-OH-D), an indicator of vitamin D status, and lipid profiles with oxidative stress in patients with type 2 diabetes mellitus (T2DM).</p> <p style="text-align: justify;"><em><strong>Methods:</strong></em> In this case-control study, 57 T2DM patients with low vitamin D status (< 30 ng/mL) and 48 T2DM patients with normal vitamin D status (> 30 ng/mL) were enrolled. Fasting concentrations of 25-OH-D, calcium, phosphorus, parathyroid hormone (PTH), lipid profiles, fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), F2-isoprostane, and oxidized-low-density lipoprotein (ox-LDL) were measured.</p> <p style="text-align: justify;"><em><strong>Results:</strong></em> The mean fasting serum concentrations of 25-OH-D, calcium, and phosphorus in patients with low vitamin D status were significantly lower than in controls (p < 0.001). The mean concentrations of ox-LDL, F2-isoprostane, total cholesterol, and LDL were significantly higher in patients with low vitamin D status than in controls. There was a negative correlation between vitamin D levels and F2-isoprostane (r = 0.647and P = 0.0001), LDL (r = -0.218 and P = 0.030), and ox-LDL (r = -0.637 and P = 0.0001).</p> <p style="text-align: justify;"><em><strong>Conclusions:</strong></em> The results of present study indicated that serum concentrations of 25-OH-D were inversely correlated with F2-isoprostane, LDL, and ox-LDL. Therefore, vitamin D may have a beneficial effect on the control of lipid profiles and oxidative stress in T2DM patients.</p> Diabetes mellitus type 2, F2-isoprostane, Oxidative stress, Ox-LDL, Vitamin D 26 32 http://rbmb.net/browse.php?a_code=A-10-1-61&slc_lang=en&sid=1 Mohammad Hassan Javanbakht 10031947532846006161 10031947532846006161 No Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Hamed Mohammady 10031947532846006162 10031947532846006162 No Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Koorosh Fooladsaz 10031947532846006163 10031947532846006163 No Department of Clinical Biochemistry, Zanjan University of Medical Sciences, Zanjan, Iran Maryam Razzaghi 10031947532846006164 10031947532846006164 No Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Mahnaz Zarei 10031947532846006165 10031947532846006165 No Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Mahmoud Djalali mjalali87@yahoo.com 10031947532846006166 10031947532846006166 Yes Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.