en بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> The fluctuation in serum caveolin-1 (Cav-1) concentrations is an important indicator of many&nbsp;diseases. Irrespective of the actual cause, a significant reduction of serum Cav-1 is associated with a&nbsp;significant increase in insulin secretion and hyperinsulinemia. The aim of the current study was to evaluate&nbsp;the relationship between serum Cav-1, serum vaspin and visfatin in newly diagnosed men with T2DM.<br> <br> <strong><em>Methods:</em></strong> Eighty-two newly diagnosed men with T2DM were matched for age and body mass indexes&nbsp;(BMIs) with a similar number of non-diabetic men. Serum Cav-1, vaspin and visfatin were assessed through&nbsp;enzyme-linked immunosorbent assay. Fasting serum glucose (FSG), glycohaemoglobin A1C (HbA1c)&nbsp;were both measured using automated method. In addition, waist-circumferences, waist-hip ratio, systolic&nbsp;(SBP), and diastolic blood pressure (DBP) were also obtained.<br> <br> <em><strong>Results:</strong></em> Serum concentration of Cav-1(ng/mL) was significantly low in men newly diagnosed with T2DM,&nbsp;(2.334&plusmn;0.7627) compared with non-diabetic controls (4.321&plusmn;1.143), p< 0.0001. In contrast, patients with&nbsp;T2DM exhibited significantly higher serum concentrations of vaspin and visfatin (ng/mL), 142.4&plusmn;60.53)&nbsp;and 2.99&plusmn;1.091), than controls, 81.53&plusmn;39.32) and 1.456&plusmn;0.654), respectively, p< 0.0001. Expectedly,&nbsp;patients with T2DM have significantly higher FSG, HbA1c, systolic blood pressure (SBP), and diastolic&nbsp;blood pressure (DBP).&nbsp;<br> <br> <strong><em>Conclusions:</em></strong> There was an inverse significant relationship between Cav-1 and vaspin, visfatin, HbA1c,&nbsp;FSG, and hypertension. This study suggests that serum Cav-1 can be used as a diagnostic marker to predict&nbsp;T2DM in individuals and families under high risk.</div> Caveolin-1, HbA1c, Insulin resistance, T2DM, Vaspin, Visfatin. 299 309 http://rbmb.net/browse.php?a_code=A-10-838-3&slc_lang=en&sid=1 Hameed Hussein Ali 100319475328460012876 100319475328460012876 No Departemnt of Chemistry, College of Sciences, University of Anbar, Ramadi, Al-Anbar province Iraq. Khalid Al-rawi 100319475328460012877 100319475328460012877 No Departemnt of Chemistry, College of Sciences, University of Anbar, Ramadi, Al-Anbar province Iraq. Yousif Khalaf 100319475328460012878 100319475328460012878 No Department of Clinical Laboratory Sciences, College of Pharmacy, University of Anbar, Ramadi, Al-Anbar province, Iraq. Shakir Alaaraji 100319475328460012879 100319475328460012879 No Department of Chemistry, College of Education for Pure Sciences, University of Anbar, Ramadi, Al-Anbar province, Iraq. Bilal Aldahham 100319475328460012880 100319475328460012880 No Department of Applied Chemistry, College of Applied Sciences, University of Anbar, Ramadi, Al-Anbar province, Iraq. Muthanna Awad 100319475328460012881 100319475328460012881 No Department of Chemistry, College of Education for Pure Sciences, University of Anbar, Ramadi, Al-Anbar province, Iraq. Osamah Al-ani 100319475328460012882 100319475328460012882 No Odessa National Medical University, Odessa, 65000, Ukraine. 6 University of Al-Rasheed College, Baghdad, Iraq. Faisal Al-ani 100319475328460012883 100319475328460012883 No Odessa National Medical University, Odessa, 65000, Ukraine. 6 University of Al-Rasheed College, Baghdad, Iraq. Aus Tariq Ali drali@europe.co 100319475328460012884 100319475328460012884 Yes University of Al-Rasheed College, Baghdad, Iraq